If you are contemplating a new year's health kick, you could be forgiven for feeling a little overwhelmed.
If you are contemplating a new year's health kick, you could be forgiven for feeling a little overwhelmed.
My name is Tim and I'm a cheese addict. But what I've been discovering recently has shaken me to the core.
Scientists in Cambridge have built a virtual reality (VR) 3D model of cancer, providing a new way to look at the disease.
Children in the UK exceed the maximum recommended sugar intake for an 18-year-old by the time they are 10, according to experts.
A clinical trial has been launched to see if a breath test could detect the presence of cancer.
A woman has celebrated the first anniversary of having her leg amputated - by running a 5k race.
Breast cancer is a disease that overwhelmingly affects women, but men get it too. Peter Bagnall is one of them.
It has been a remarkable year of promise in medical science - from reversing blindness and paralysis to progress in cancer and infertility.
The University of Warwick has enlisted some of the country's leading sleep experts in order to "warn Santa Claus of the health risks of flying all night".
When actor Stephen McGann recently tweeted about his frustration with people who pressurised others to drink alcohol, he received an outpouring of support on social media.
A couple who underwent IVF treatment paid for by friends from a Facebook group have had a baby girl.
Antrodan, a unique protein-bound polysaccharide derived from the fungal mycelia of Antrodia cinnamomea, has been reported to exhibit antitumor and anti-metastatic effects on Lewis lung carcinoma (LLC) cells through direct action and immunomodulation in vitro. In this study, we investigated the combined treatment of antrodan with an anti-cancer drug-cisplatin-and its underlying molecular mechanisms of action in a mouse xenograft tumor model. C57BL/6 mice were implanted (s.c.) with LLCs for nine days, before administration with only antrodan (20 mg/kg and 40 mg/kg; p.o.) daily, only cisplatin (1 mg/kg; i.p.) twice per week, or a combination of both for an additional 28 days. As expected, antrodan on its own significantly inhibited metastasis of lung and liver tissues, while treatment with cisplatin only merely inhibited metastasis of the liver. Antrodan exhibited efficient adjuvant therapy in combination with cisplatin, by inhibiting the activities of the plasma urokinase plasminogen activator (uPA) and the liver matrix metalloproteinase 9 (MMP-9), as well as by inhibiting the phosphorylation of p38 and extracellular signal-regulated kinase 2 (ERK2) in lung and liver tissues. In addition, antrodan effectively ameliorated cisplatin-induced kidney dysfunction when treated combinatorially, as evidenced by a decrease in cisplatin-induced blood urea nitrogen (BUN) levels in plasma and in the level of p38 phosphorylation in the kidney. Mechanistically, the actions of antrodan on its own involved (i) reducing the activities of uPA and MMP-2 and -9 in plasma; (ii) reducing protein expression of MMP-2/9, and the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinases (JNKs), and p38 in lung and liver tissues; and (iii) enhancing immune system functions resulting in the promotion of an anti-metastatic response through immunomodulation, by increasing interferon-γ (IFN-γ) levels and decreasing interleukin-6 (IL-6) levels in plasma. These results demonstrated that antrodan provides a novel, complementary therapeutic strategy against cancer metastasis, by attenuating the activities of MMP-2 and -9 through the modulation of STAT3/MAPK/ERK/JNK signaling pathways, and of the host’s immune system.
Music festival-goers across Australia have been warned about a "dangerous orange pill", after a young man died of a suspected drug overdose.
Arooj Aftab, 22, is an influencer who is known for her baggy fashion style. But what her 7,500 Instagram followers don't know is there's a big reason she chooses to wear oversized clothes - which she has kept secret until now.
Fewer than half of people eligible for a NHS health check in England have taken up the offer, despite it being free to everyone over 40.
Ruba and Saqib both carry a gene for an incurable condition, which means their children have a one-in-four chance of dying in early childhood. They've already lost three. Ruba now wants IVF, to select a healthy embryo. Saqib is putting his trust in Allah. And some relatives want them to separate and remarry.
Spinal surgery for unborn babies with the birth defect spina bifida is to be made routinely available on the NHS in England, officials have announced.
Every year, there are always more baby boys than girls born in England and Wales. Fact. Why?
A South African jazz musician who played his guitar during brain surgery is making a successful recovery.
England's top doctor has accused the food industry of "failing the public" and is calling for taxes on unhealthy food high in sugar and salt.